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According to the recent increase of antibiotic-uses, the possibility of the occurrence of intolerance and superinfection became increased. So we surveyed the drug interaction of antibiotics in order to inhibit antibiotic-related side effect. This study was accomplished for the antibiotic-administered inpatients by enteral or parenteral route in Chonnam University Hospital at one day of Jan., April and July in 1990. The antibiotic-administered inpatients occupied 57.6% of total 1,760 drug-administered inpatients. On clinical department, surgery occupied the highest value of 47.5% of antibiotic-administered patient. On the route of antibiotic administration, injection occupied 82.5%, internal medicine 10.3% and the combination of injection & internal medicine 7.2%. On antibiotic dosage form, injection occupied 89.7% and internal medicine 17.5%. On the number of used antibiotic, one occupied 26.4%, two 56.8%,thus these two cases 83.2%. The average number of antibiotic used by a patient was 1.9. The possible occurrence rate of drug interaction of antibiotics was 69%. As the number of used drug increased, the occurrence possibility of drug interaction of antibiotics tended to increase. The possible occurrence rate of drug interaction of antibiotics reached 100% in above 21 drug-used cases. Not only the increase of anti-infective effect but also the increase of toxicity could result from the highest value of 691 cases of drug interaction between bactericidal antibiotics. In these cases we should consider the benefit/risk ratio. Most inpatients used about two antibiotics. In these cases we should consider the benefit/risk ratio. Most inpatients used about two antibiotics and above 2/3 of those could experience drug interaction. So we should carefully monitor the drug interaction of antibiotics and provide drug information to health team in order to prevent antibiotic interaction-induced undesirable side effect.
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